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陈红岩

生命科学学院

研究方向:遗传学

个人简历

陈红岩:女,1975年8月出生,汉族人,遗传学博士、复旦大学讲师。1994.9-1998.7 河南师范大学生命科学院, 获生物技术专业学士学位;1998.9-2001.7 厦门大学生物系,获生化及分子生物学专业硕士学位。期间主要从事流行病的诊断试剂盒开发研究及转基因植物生产口服疫苗的研究;2001.9-2004.7复旦大学 生命科学院获遗传学专业博士学位。主要从事血友病B的基因治疗研究;2004.7 -2005.10,第二军医大学和上海富纯中南生物技术有限公司做博士后,主要从事抗体药物的研究开发,课题项目负责人;2005.10-2008.2 新加坡国立神经科学研究所做博士后,及2008.3-2008.8新加坡中央医院做研究科学家期间主要从事遗传性神经肌肉疾病的分子治疗;期间协助申请并获得了两个项目的资助: 1.Strategy for therapy in myotonic dystrophy (DM1): Correction of expanded CUG repeats in mutant DMPK gene transcripts in DM1 cell lines. NMRC funded for 2 years. 2.Correction of expanded CAG repeats in the Huntingtin transcript for the treatment of Huntington’s disease. Singheath funded for 2 years.本人也获得了 Singapore Millennium Foundation scholarship的资助。 2008.12-至今 复旦大学生命科学学院讲师。主要从事肺癌,脑胶质瘤等肿瘤的分子遗传流行病学研究,参与开展了关于VEGFA基因SNPs与脑胶质瘤易感性的研究,研究数据已经整理成文并已被Journal of Clinical Neuroscience杂志接受。另外还参与了脑胶质瘤GWAS结果在中国人群中的验证工作,研究成果已经被American Journal of Epidemiology接受。

发表的研究性文章:

1.Chen Hongyan, Chen Y, Zhao Y, Fan W, Zhou K, Liu Y, Zhou L, Mao Y, Wei Q, Xu J, Lu D. ssociation of Sequence Variants on Chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) With Glioma Susceptibility in a Chinese Population.Am J Epidemiol. Am J Epidemiol. 2011;173(8):915-22.

2.Chen Hongyan, Gu Y, Wu W, Chen D, Li P, Fan W, Lu D, Zhao F, Qiao N, Qiu H, Fu C, Mao Y, Zhao Y. Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population.J Clin Neurosci. 2011;18(4):549-53.

3.Ling Y, Li X, Gu Q, Chen Hongyan,Lu D, Gao X. A common polymorphism rs3781637 in MTNR1B is associated with type 2 diabetes and lipids levels in Han Chinese individuals. Cardiovasc Diabetol. 2011;10:27.

4.Zhou K, Hu D, Lu J, Fan W, Liu H, Chen Hongyan, Chen G, Wei Q, Du G, Mao Y, Lu D, Zhou L.A genetic variant in the APE1/Ref-1 gene promoter -141T/G may modulate risk of glioblastoma in a Chinese Han population.BMC Cancer. 2011;11:104.

5.Wu Q, Zhan X, Dou T, Chen Hongyan, Fan W, Zhou K, Zhang H, Zheng H, Cai Y, Zhao Y, Huang F, Zhou L, Mao Y, Lu D. CTLA4 A49G polymorphism shows significant association with glioma risk in a Chinese population. Biochem Genet. 2011;49(3-4):190-201.

6.Han B, Gao G, Wu W, Gao Z, Zhao X, Li L, Qiao R, Chen Hongyan, Wei Q, Wu J, Lu D. Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.Lung Cancer. 2011;72(2):238-43.

7.Zhao Y, Xie L, Li P, Song J, Qu T, Fan W, Chen Hongyan, Chen D, Lu D, Zhou L, Mao Y.A novel CCM1 gene mutation causes cerebral cavernous malformation in a Chinese family.J Clin Neurosci. 2011;18(1):61-5.

8.Li R, Zhao Y, Fan W, Chen H, Chen Hongyan, Liu Y, Chen G, Zhou K, Huang F, Mao Y, Zhou L, Lu D, Shugart YY. Possible association between polymorphisms of human vascular endothelial growth factor A gene and susceptibility to glioma in a Chinese population. Int J Cancer 2011,128:166-175.

9.Zhenchao Ruan, Yao Zhao, Lili Yan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, KeKe Zhou, Yin Mao, Liangfu Zhou, Yan Huang, Daru Lu. Single nucleotide polymorphisms in IL-4Ra, IL-13 and STAT6 genes occurs in brain glioma. Front Biosci 2011,3:33-45.

10.Shujie Wang, Yao Zhao, Zhenchao Ruan, Hongyan Chen, Weiwei Fan, Juxiang Chen, Qihan Wu, Ji Qian, Tianbao Zhang, Yan Huang*, Daru Lu*. Association between EGF +61 G/A and glioma risk in a Chinese population. BMC cancer 2010;10:221.

11.Zhong Yu, Huang Y, Huang Y, Zhang T, Ma C, Zhang S, Fan W, Chen Hongyan, Qian J, Lu D.* Effects of O6-methylguanine-DNA methyltransferase (MGMT) polymorphisms on cancer: a meta-analysis. Mutagenesis.2010;25(1):83-95.

12.Chen Hongyan, Paramasivam Kathirvel, Woon Chee Yee, et al. Correction of dystrophia yotonica type 1 pre-mRNA transcripts by artificial trans-splicing. Gene Therapy. 2009;16(2):211-7.

13.Zhu Huanzhang, Chen Hongyan, Feng Dengmin et al. Eliminating bacteria backbone of naked DNA enhanced hFIX expression and reduced inflammatory response in mice. Biomedicine & Pharmacotherapy. 2009,63(2):129-35. (Co-first author)

14.Chen Hongyan, Zhu Huanzhang, Lu Bin et al.Enhancement of naked FⅨDNA expression by chloroquine in mice. Acta pharmacologica Sinica. 2004, 25 (5): 570-575.

15.陈红岩,张军,高毅等。乙肝病毒表面抗原基因在花生中的遗传转化及免疫性检测。生物技术通讯 2002,13(4):245-250.

16.陈红岩,高毅,张军等。转基因植物疫苗的发展状况。国外医学?流行病学传染病学分册 2001,28(6):246-249.

17.杜海莲,张军,肖平,韩冬丽,陈红岩等。马铃薯遗传转化系统的优化及禽流感病毒(H5N1)基因的导入。厦门大学学报(自然科学版) 2000,39(5):699-706。